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Knockout Rats The Easy Way
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Groups of genetically engineered fluorescent rats have given birth to offspring that lack their surreal green glow. The pups’ appearances were altered in the embryonic stage of development by an engineered zinc finger protein that knocked out the gene that illuminated their parents, according to a new paper in Science
The parents of both of these mice express green fluorescent protein, but in the mouse on the left, the fluorescent-marker gene had been knocked out by a zinc finger nuclease
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